Research in our group is focused on gaining a better understanding of noradrenergic transmission in arteries and veins and how this signaling is altered in cardiovascular disease states, such as hypertension. The pathophysiological mechanisms of neural control in the vasculatureare being probed in vitro using various pharmacological agents along with continuous amperometry and video imaging. Microseparation techniques are also being employed to measure extracellular and circulating levels of norepinephrine and its metabolites in order to better understand how release, uptake and metabolism are altered in the disease state. In a new thrust in the group, the normal pathophysiology of enterochromaffin cells residing in the intestinal mucosal layer and their control of gastrointestinal function is being studied. To this end, continuous amperometry is being used along with various pharmacological agents to record real time release of 5-hydroxytryptamine (5-HT, serotonin). All of our work is performed collaboratively with researchers in the Departments of Physiology, Pharmacology and Toxicology, and Human Medicine.
View http://www.chemistry.msu.edu/faculty/swain for the most current list of publications.
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